programmed cell death aging and senescence pdf Monday, December 14, 2020 10:11:13 AM

Programmed Cell Death Aging And Senescence Pdf

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Cells go through a natural life cycle which includes growth, maturity, and death.

Metrics details. There have been enough cell death modes delineated in the biomedical literature to befuddle all cell death researchers. Mulling over cell death from the viewpoints of the host tissue or organ and of the host animal, we construe that there should be only two physiological cell death modes, i. Other death modes described in the literature are ad-hoc variants or coalescences of some of these four basic ones in different physiological or pathological situations.

ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases

Abstract: Increasing evidence suggests an important role for programmed cell death PCD pathways in aging phenotypes across species. PCD is critical to the homeostasis of tissues maintained by cell division, for example, the blood and the lining of the gut. During aging, accumulated cellular damage and non-optimal systemic signaling can cause too little cell death hyperproliferation and cancer , or too much cell death tissue atrophy and ectopic cell death , thereby limiting tissue function and life span. For these reasons PCD pathways are promising targets for interventions in aging and aging-related diseases: reactivation of PCD may be beneficial in clearing cancerous and senescent cells, whereas inhibiting PCD may help prevent muscle atrophy and nervous system degeneration. The mechanisms by which cells die can be divided into two general types: programmed cell death PCD mechanisms that require energy, and necrotic cell death mechanisms that do not Elmore, One type of PCD is apoptosis , where, in response to extrinsic or intrinsic death signals, pro-apoptotic factors such as cytochrome C are released from the mitochondria , a cascade of proteases called caspases are activated, and the cell undergoes a series of characteristic morphological and biochemical changes including shrinkage, membrane blebbing, and DNA fragmentation. Cell death signals can be intracellular intrinsic such as DNA damage or oxidative stress , or extracellular extrinsic such as the cytokine hormone called tumor necrosis factor.

Aspects of programmed cell death during leaf senescence of mono- and dicotyledonous plants

Progressive telomere shortening during lifespan is associated with restriction of cell proliferation, genome instability and aging. Apoptosis and senescence are the two major outcomes upon irreversible cellular damage. Here, we show a transition of these two cell fates during aging of telomerase deficient zebrafish. In young telomerase mutants, proliferative tissues exhibit DNA damage and pdependent apoptosis, but no senescence. However, these tissues in older animals display loss of cellularity and senescence becomes predominant. Tissue alterations are accompanied by a pro-proliferative stimulus mediated by AKT signaling. Upon AKT activation, FoxO transcription factors are phosphorylated and translocated out of the nucleus.

Leaf senescence is a highly regulated stage in the plant life cycle, leading to cell death, recently examined as a type of the programmed cell death PCD. The comet assay, a sensitive method revealing nonrandom internucleosomal damage that is specific for PCD, is especially useful for the detection of nDNA degradation in isolated viable cells. Simultaneously, we analyzed the mesophyll cell ultrastructure and the photosynthetic-pigment concentration in the leaves of two species, Ornithogalum virens and Nicotiana tabacum , representing mono- and dicotyledonous plants which differ in the pattern of leaf differentiation. These investigations demonstrated that, in both species, the comet assay revealed nDNA degradation in yellow-leaf protoplasts containing chloroplasts that showed already changed ultrastructure swelled or completely degraded thylakoids and cell nuclei with a significant condensation of chromatin. There was no nDNA degradation in green-leaf protoplasts containing differentiated chloroplasts with numerous grana stacks and nuclei with dispersed chromatin. The analysis of intermediate developmental stage showed that the degradation of nDNA precedes condensation of nuclear chromatin.

The aging process worsens the human body functions at multiple levels, thus causing its gradual decrease to resist stress, damage, and disease. Specific increases of ROS level have been demonstrated as potentially critical for induction and maintenance of cell senescence process. Causal connection between ROS, aging, age-related pathologies, and cell senescence is studied intensely. Senescent cells have been proposed as a target for interventions to delay the aging and its related diseases or to improve the diseases treatment. Therapeutic interventions towards senescent cells might allow restoring the health and curing the diseases that share basal processes, rather than curing each disease in separate and symptomatic way. Here, we review observations on ROS ability of inducing cell senescence through novel mechanisms that underpin aging processes.


PDF | Increasing evidence suggests an important role for programmed cell death (PCD) pathways in apoptosis or senescence, depending upon the signal and.


Aspects of programmed cell death during leaf senescence of mono- and dicotyledonous plants

Cellular senescence acts as a brake pedal of the car in our system to avert accidents like cancer. Recent studies provide the lines of evidence that support how senescence contributes towards aging and age-associated diseases. How senescence plays a pivotal role in aging and cell death and their inter-relation have been discussed in detail.

The Pivotal Role of Senescence in Cell Death and Aging: Where Do We Stand?

Programmed cell death PCD ; sometimes referred to as cellular suicide [1] is the death of a cell as a result of events inside of a cell, such as apoptosis or autophagy. For example, the differentiation of fingers and toes in a developing human embryo occurs because cells between the fingers apoptose ; the result is that the digits are separate.

2 Comments

Erik J. 17.12.2020 at 18:22

Oncotarget a primarily oncology-focused, peer-reviewed, open access, biweekly journal aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Tonya R. 20.12.2020 at 18:19

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