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Caloric Restriction Delays Disease Onset And Mortality In Rhesus Monkeys Pdf

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Disclosures: L. No other disclosures were reported.

Regret for the inconvenience: we are taking measures to prevent fraudulent form submissions by extractors and page crawlers. Received: December 23, Published: June 16, Citation: Breeding Z. The implications of calorie restriction on longevity and health span.

Calorie restriction and its impact on gut microbial composition and global metabolism

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Caloric restriction CR without malnutrition extends lifespan and delays the onset of age-related disorders in most species but its impact in nonhuman primates has been controversial. In the late s two parallel studies were initiated to determine the effect of CR in rhesus monkeys. The University of Wisconsin study reported a significant positive impact of CR on survival, but the National Institute on Aging study detected no significant survival effect.

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Caloric restriction CR without malnutrition increases longevity and delays the onset of age-associated disorders in short-lived species, from unicellular organisms to laboratory mice and rats. These data contrast with observations in the NIA intramural study report, where a difference in survival was not detected between control-fed and CR monkeys. A comparison of body weight of control animals from both studies with each other, and against data collected in a multi-centred relational database of primate ageing, suggests that the NIA control monkeys were effectively undergoing CR.

Calorie Restriction in Mammals and Simple Model Organisms

Vaughan et al. The differences between the two studies have been stressed 5 , 6. Particularly, the control group of Colman et al. However, it seems possible to go a step further than Vaughan et al. In the study showing no effect of diet restriction 2 , females lived for 28 years and males for 35 years, while control monkeys lived for 26 years and diet-restricted ones for 29 years in the study reporting a life-span increase 3 , 4.

Skip to search form Skip to main content You are currently offline. Some features of the site may not work correctly. DOI: Colman and R. Anderson and S. Johnson and E. Kastman and Kristopher J.

Cava E , Fontana L ,. Will calorie restriction work in humans?. Aging Albany NY. Calorie Restriction CR without malnutrition slows aging and increases average and maximal lifespan in simple model organisms and rodents. In rhesus monkeys long-term CR reduces the incidence of type 2 diabetes, cardiovascular disease and cancer, and protects against age-associated sarcopenia and neurodegeneration.


Caloric restriction (CR), without malnutrition, delays aging and extends life span in diverse species; however, its effect on resistance to illness and mortality in primates has not been clearly established.


Caloric restriction delays disease onset and mortality in rhesus monkeys

Calorie restriction CR is a dietary regimen that reduces calorie intake without incurring malnutrition or a reduction in essential nutrients. It has long been recognized as a natural strategy for promoting health, extending longevity, and prevents the development of metabolic and age-related diseases. In the present review, we focus on the general effect of CR on gut microbiota composition and global metabolism.

Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

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3 Comments

Eleanor H. 16.12.2020 at 03:10

Caloric restriction CR , a reduction of food intake while avoiding malnutrition, can delay the onset of cancer and age-related diseases in several species, including mice.

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