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Cognitive deficits in schizophrenia and other neuropsychiatric disorders: Convergence of preclinical and clinical evidence View all 29 Articles. Mammalian memory is the result of the interaction of millions of neurons in the brain and their coordinated activity.
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It is widely believed that spatial learning and memory require long-term changes in a brain region called the hippocampus. This review challenges this received wisdom and uses recent evidence to argue that, rather than encoding or storing spatial memories, the hippocampus may use spatial information to resolve conflict and reduce uncertainty. This may explain its role in anxiety as well as memory. Recent studies using transgenic mice lacking NMDA receptors in the hippocampus challenge the long-standing hypothesis that hippocampal long-term potentiation-like mechanisms underlie the encoding and storage of associative long-term spatial memories. However, it may not be the synaptic plasticity-dependent memory hypothesis that is wrong; instead, it may be the role of the hippocampus that needs to be re-examined.
It has been 70 years since Donald Hebb published his formalized theory of synaptic adaptation during learning. Our understanding of the processes underlying learning and memory has been dominated by the view that synapses are the principal site of information storage in the brain. This view has received substantial support from research in several model systems, with the vast majority of studies on the topic corroborating a role for synapses in memory storage. Furthermore, an increasing number of non-synaptic mechanisms have emerged that are also capable of acting as memory substrates. In this review, we address the key findings from the synaptic plasticity literature that make these phenomena such attractive memory mechanisms.
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Consolidation of implicit memory in the invertebrate Aplysia and explicit memory in the mammalian hippocampus are associated with remodeling and growth of preexisting synapses and the formation of new synapses.Darius G. 12.12.2020 at 22:29
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